Many articles on oral docetaxel and paclitaxel have been published in high ranking professional journals. Leading researchers have presented several times on these innovative formulations at keynote lectures at the ASCO and AACR annual meetings.

Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer. Yu H, Hendrikx JJ, Rottenberg S, Schellens JH, Beijnen JH, Huitema AD.AAPS J. 2016 Mar;18(2):362-71. doi: 10.1208/s12248-015-9838-1. Epub 2015 Nov 24.PMID: 26603889
Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model. Hendrikx JJ, Lagas JS, Song JY, Rosing H, Schellens JH, Beijnen JH, Rottenberg S, Schinkel AH. Int J Cancer. 2016 Feb 1;138(3):758-69. doi: 10.1002/ijc.29812. Epub 2015 Sep 21. PMID: 26297509
Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation. Hendrikx JJ, Lagas JS, Wagenaar E, Rosing H, Schellens JH, Beijnen JH, Schinkel AH. Br J Cancer. 2014 May 27;110(11):2669-76. doi: 10.1038/bjc.2014.222. Epub 2014 Apr 29. PMID: 24781280
Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer. Helgason HH, Koolen SL, Werkhoven Ev, Malingre MM, Kruijtzer CM, Huitema AD, Schot ME, Smit WM, Beijnen JH, Schellens JH. Curr Clin Pharmacol. 2014 May;9(2):139-47.
Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet. Moes JJ, Stuurman FE, Hendrikx JJ, Marchetti S, Huitema AD, Beijnen JH, Schellens JH, Nuijen B. Drug Deliv Transl Res. 2013 Jun;3(3):243-51. doi: 10.1007/s13346-012-0127-6. PMID: 25788133
Taxanes: old drugs, new oral formulations. Jibodh RA, Lagas JS, Nuijen B, Beijnen JH, Schellens JH. Eur J Pharmacol. 2013 Oct 5;717(1-3):40-6. doi: 10.1016/j.ejphar.2013.02.058. Epub 2013 May 7. Review.PMID: 23660368
P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.Hendrikx JJ, Lagas JS, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.Int J Cancer. 2013 May 15;132(10):2439-47. doi: 10.1002/ijc.27912. Epub 2012 Nov 14.PMID: 23090875
Pharmaceutical development and preliminary clinical testing of an oral solid dispersion formulation of docetaxel (ModraDoc001). Moes JJ, Koolen SL, Huitema AD, Schellens JH, Beijnen JH, Nuijen B. Int J Pharm. 2011 Nov 28;420(2):244-50. doi: 10.1016/j.ijpharm.2011.08.041. Epub 2011 Sep 2. PMID: 21907780
From mouse to man: predictions of human pharmacokinetics of orally administered docetaxel from preclinical studies. Koolen SL, van Waterschoot RA, van Tellingen O, Schinkel AH, Beijnen JH, Schellens JH, Huitema AD. J Clin Pharmacol. 2012 Mar;52(3):370-80. doi: 10.1177/0091270010397051. Epub 2011 Apr 19. PMID: 21505085
Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer. Koolen SL, Oostendorp RL, Beijnen JH, Schellens JH, Huitema AD. Br J Clin Pharmacol. 2010 May;69(5):465-74. doi: 10.1111/j.1365-2125.2010.03621.x. PMID: 20573082
Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel. Koolen SL, Beijnen JH, Schellens JH. Clin Pharmacol Ther. 2010 Jan;87(1):126-9. doi: 10.1038/clpt.2009.233. Epub 2009 Nov 18. Review. PMID: 19924122
Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors. Oostendorp RL, Huitema A, Rosing H, Jansen RS, Ter Heine R, Keessen M, Beijnen JH, Schellens JH. Clin Cancer Res. 2009 Jun 15;15(12):4228-33. doi: 10.1158/1078-0432.CCR-08-2944. Epub 2009 Jun 9. PMID: 19509162
Metabolism of docetaxel in mice. Bardelmeijer HA, Roelofs AB, Hillebrand MJ, Beijnen JH, Schellens JH, van Tellingen O. Cancer Chemother Pharmacol. 2005 Sep;56(3):299-306. Epub 2005 Apr 30.PMID: 15864592
Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093). Kuppens IE, Bosch TM, van Maanen MJ, Rosing H, Fitzpatrick A, Beijnen JH, Schellens JH. Cancer Chemother Pharmacol. 2005 Jan;55(1):72-8. Epub 2004 Aug 17. PMID: 15316750
Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview. Kruijtzer CM, Beijnen JH, Schellens JH. Oncologist. 2002;7(6):516-30. Review. PMID: 12490739
Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir. Bardelmeijer HA, Ouwehand M, Buckle T, Huisman MT, Schellens JH, Beijnen JH, van Tellingen O. Cancer Res. 2002 Nov 1;62(21):6158-64.PMID: 12414642
Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel. Malingré MM, Ten Bokkel Huinink WW, Mackay M, Schellens JH, Beijnen JH.Eur J Clin Pharmacol. 2001 Jul;57(4):305-7. PMID: 11549208
Oral delivery of taxanes.Malingré MM, Beijnen JH, Schellens JH.Invest New Drugs. 2001 May;19(2):155-62. Review.PMID: 11392449
Progress in the development of alternative pharmaceutical formulations of taxanes. Nuijen B, Bouma M, Schellens JH, Beijnen JH. Invest New Drugs. 2001 May;19(2):143-53. Review. PMID: 11392448
Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel. Malingré MM, Richel DJ, Beijnen JH, Rosing H, Koopman FJ, Ten Bokkel Huinink WW, Schot ME, Schellens JH. J Clin Oncol. 2001 Feb 15;19(4):1160-6. PMID: 11181682
Modulation of oral bioavailability of anticancer drugs: from mouse to man. Schellens JH, Malingré MM, Kruijtzer CM, Bardelmeijer HA, van Tellingen O, Schinkel AH, Beijnen JH. Eur J Pharm Sci. 2000 Dec;12(2):103-10. Review. PMID: 11102737


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